The Function of CALR

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis.

Protein names

Recommended name:

Calreticulin

Short name:

CRP55

Alternative name(s):

Calregulin
Endoplasmic reticulum resident protein 60
ERp60
HACBP
grp60

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Top Gene-Substance Interactions

CALR Interacts with These Diseases

Substances That Increase CALR

Substances That Decrease CALR

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical