The Function of CALD1

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration.

Protein names

Recommended name:

Caldesmon

Short name:

CDM

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Top Gene-Substance Interactions

CALD1 Interacts with These Diseases

Substances That Increase CALD1

Substances That Decrease CALD1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical