Summary of C3

A complement system is a group of proteins that move freely through your bloodstream. The proteins work with your immune system and play a role in the development of inflammation. Low levels of Complement C3 cause susceptibility to infections and are associated with some autoimmune conditions, while high levels cause chronic inflammation.


The Function of C3

Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:8376604, PubMed:2909530, PubMed:9059512, PubMed:10432298, PubMed:15833747, PubMed:16333141, PubMed:19615750).

Protein names

Recommended name:

Complement C3

Short name:

ASP

Alternative name(s):

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
C3bc
C3adesArg

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Top Gene-Substance Interactions

C3 Interacts with These Diseases

Substances That Increase C3

Substances That Decrease C3

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical