The Function of BMP2

Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).

Protein names

Recommended name:

Bone morphogenetic protein 2

Short name:

BMP-2

Alternative name(s):

Bone morphogenetic protein 2A
BMP-2A

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Top Gene-Substance Interactions

BMP2 Interacts with These Diseases

Substances That Increase BMP2

Substances That Decrease BMP2

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical