Summary of BCO1
The BCO1 gene is responsible for making a protein (BCMO1) that is involved in the conversion of beta-carotene into retinoic acid (active form of vitamin A) that can be used by the body.
Vitamin A is crucial for your brain, immune system, skin, eyes, teeth, bones and for the formation of hormones. Vitamin A protects our eyes and skin from UV damage, so it will allow you to get UV and limit skin cancer risk [R].
Vitamin A is important for thyroid hormone and vitamin D function. Vitamin A might benefit obesity [R].
Recommended name:Beta-carotene oxygenase 1
Top Gene-Substance Interactions
Substances That Increase BCO1
Substances That Decrease BCO1
Read: The Importance of Real Vitamin A (Retinol)
Vitamin A/Retinol is crucial for activating the Retinoid X Receptors (RXR), which is required for PPAR activation (DHA can also activate RXR) (R)
RXR is needed to activate the vitamin D receptor (VDR) and the Thyroid Hormone Receptor (THR). In simple English, this means if you're deficient in vitamin A you can take all the vitamin D you want and it won't make that much of a difference because you need adequate vitamin A to make these work properly.
It's especially important for your gut immune system. Vitamin
Vitamin A-deficient animals have lower adrenal hormone production. (R) Another study shows that Vitamin A deficient rats had excess cortisol and a hyper cortisol response. When they were given vitamin A their cortisol normalized. (R)
Vitamin A might benefit obesity by increasing UCP1 in mice, which increases heat loss/fat burning. But studies in humans haven't had the same results. (R)
Vitamin A/Retinol plays a central role in increasing neuroplasticity and neurogenesis. It's critical to our hippocampus and hypothalamus, which controls memory and wakefulness, respectively. (R)
Indeed, vitamin A is important for long-term potentiation (LTP), which is important to form memories. (R)
Vitamin A deficiency causes a circadian dysrhythmia, which in turn results in cognitive dysfunction. (R)
Vitamin A is critical to have a normal circadian rhythm and Animals fed a Vitamin A (retinol) deficient diet have a circadian rhythm that doesn't work in synchrony. (R)
When Vitamin A causes a circadian dysrhythmia it likely results in cognitive dysfunction. (R)
The rhythms of these antioxidant enzymes are important because in some parts of the day we do better with more internal antioxidants, while at other times we do better with less.
Vitamin A-deficient animals also had reduced periods of wakefulness and energy expenditure (locomotor activity). (R)
In addition to being important for daily rhythms, retinoic acid is also important for seasonal rhythms. (R)
Vitamin A does compete with vitamin D and K2 and studies show higher vitamin A is associated with lower bone density (R).