Summary of BCL2

Suppresses controlled cell death in a number of cell systems. The regulatory role is dependent upon this gene's control of mitochondrial membrane permeability.

It's better to have this gene increased most of the time. Exceptions: cancer
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The Function of BCL2

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).

Protein names

Recommended name:

Apoptosis regulator Bcl-2

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Top Gene-Substance Interactions

BCL2 Interacts with These Diseases

Substances That Increase BCL2

Substances That Decrease BCL2

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity