The Function of BAX

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Protein names

Recommended name:

Apoptosis regulator BAX

Alternative name(s):

Bcl-2-like protein 4

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Top Gene-Substance Interactions

BAX Interacts with These Diseases

Substances That Increase BAX

Substances That Decrease BAX

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity