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  1. Home
  2. Genes
  3. BAK1

BAK1 (BCL2 antagonist/killer 1)

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The Function of BAK1

In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.

Protein names

Recommended name:

Bcl-2 homologous antagonist/killer

Alternative name(s):

Apoptosis regulator BAK
Bcl-2-like protein 7
Bcl2-L-7

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BAK1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS210134 (BAK1) ??
  2. RS210135 (BAK1) ??
  3. RS210138 (BAK1) ??
  4. RS210142 (BAK1) ??
  5. RS210152 (BAK1) ??
  6. RS513349 (BAK1) ??
  7. RS5745568 (BAK1) ??
  8. RS6457730 (BAK1) ??
  9. RS6910233 (BAK1) ??
  10. RS7747216 (BAK1) ??
  11. RS9296092 (BAK1) ??
  12. RS9296095 (BAK1) ??
  13. RS9394152 (BAK1) ??
  14. RS9469457 (BAK1) ??

Top Gene-Substance Interactions

BAK1 Interacts with These Diseases

Disease Score

Substances That Increase BAK1

Substances Interaction Organism Category

Substances That Decrease BAK1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-2
  • p53
  • c-Myc
  • Sp1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • IRF-1

Tissue specificity:

Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.

Gene Pathways:

  • Apoptosis
  • Protein processing in endoplasmic reticulum

Molecular Function:

  • Identical Protein Binding
  • Protein Homodimerization Activity
  • Ion Channel Binding
  • Metal Ion Binding
  • Protein Heterodimerization Activity

Biological Processes:

  • B Cell Homeostasis
  • B Cell Apoptotic Process
  • Release Of Cytochrome C From Mitochondria
  • Blood Vessel Remodeling
  • Myeloid Cell Homeostasis
  • B Cell Negative Selection
  • Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
  • Brain Development
  • Aging
  • Mitochondrial Fusion
  • Cell Proliferation
  • Negative Regulation Of Cell Proliferation
  • Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
  • Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
  • Response To Fungus
  • Response To Mycotoxin
  • Response To Uv-C
  • Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
  • Response To Gamma Radiation
  • Positive Regulation Of Calcium Ion Transport Into Cytosol
  • Negative Regulation Of Gene Expression
  • Response To Organic Cyclic Compound
  • Cytolysis
  • Endocrine Pancreas Development
  • Animal Organ Regeneration
  • Endoplasmic Reticulum Calcium Ion Homeostasis
  • Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
  • Negative Regulation Of Peptidyl-Serine Phosphorylation
  • Cellular Response To Uv
  • Limb Morphogenesis
  • Response To Hydrogen Peroxide
  • Positive Regulation Of Apoptotic Process
  • Regulation Of Protein Homodimerization Activity
  • Regulation Of Protein Heterodimerization Activity
  • Fibroblast Apoptotic Process
  • Response To Ethanol
  • Positive Regulation Of Proteolysis
  • Regulation Of Mitochondrial Membrane Permeability
  • Post-Embryonic Camera-Type Eye Morphogenesis
  • Regulation Of Cell Cycle
  • Regulation Of Mitochondrial Membrane Potential
  • Vagina Development
  • Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
  • Thymocyte Apoptotic Process
  • Cellular Response To Mechanical Stimulus
  • Positive Regulation Of Release Of Cytochrome C From Mitochondria
  • Apoptotic Signaling Pathway
  • Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
  • Activation Of Cysteine-Type Endopeptidase Activity
  • Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
  • Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
  • Apoptotic Process Involved In Blood Vessel Morphogenesis
  • Positive Regulation Of Ire1-Mediated Unfolded Protein Response
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| null| A306_14748| apoptosis regulator BAK| AS27_02050| AS28_04631| BAK| BAK-LIKE| BCL2-antagonist| BCL2-antagonist/killer 1| Bcl-2 homologous antagonist/killer| Bcl2 homologous antagonist/killer| bcl-2 homologous antagonist/killer-like| bcl2-L-7| BCL2L7| Bcl-2-like 7| BCL2-like 7 protein| Bcl-2-likeous antagonist/killer| bcl-2-like protein 7| Bcl-2 like protein antagonist/killer| Bcl-2-like protein antagonist/killer| Bcl-2 like proteinous antagonist/killer| bcl-2ous antagonist/killer-like protein| CB1_000487033| CDN1| GW7_09865| H920_15466| M91_02581| M959_13733| MDA_GLEAN10006840| N300_03764| N301_06639| N302_14744| N303_11110| N305_13596| N306_01151| N307_09711| N308_11476| N309_03230| N310_07516| N311_08346| N312_06991| N321_02270| N322_03271| N324_05463| N325_04196| N327_03577| N328_06791| N329_10120| N330_02326| N331_09049| N332_05244| N334_14263| N335_05816| N336_07799| N340_12377| N-Bak| N-BAK1| PAL_GLEAN10007091| PANDA_002259| pro-apoptotic protein BAK| Putative Bcl-2 homologous antagonist/killer 2| Putative Bcl-2 like protein antagonist/killer 2| Putative Bcl-2-like protein antagonist/killer 2| translocator protein-like| TREES_T100009718| UY3_10564| Y1Q_012712| Y956_10855| Z169_00372| bak1
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