The Function of BACE1

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Protein names

Recommended name:

Beta-secretase 1

Short name:


Alternative name(s):

Aspartyl protease 2
Asp 2
Beta-site amyloid precursor protein cleaving enzyme 1
Beta-site APP cleaving enzyme 1
Membrane-associated aspartic protease 2

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Top Gene-Substance Interactions

BACE1 Interacts with These Diseases

Substances That Increase BACE1

Substances That Decrease BACE1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity