Summary of AXIN2

This gene encodes a protein that plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway.  Mutations in this gene have been associated with colorectal cancer (R).


The Function of AXIN2

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.

Protein names

Recommended name:

Axin-2

Alternative name(s):

Axin-like protein
Axil
Axis inhibition protein 2
Conductin

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Top Gene-Substance Interactions

AXIN2 Interacts with These Diseases

Substances That Increase AXIN2

Substances That Decrease AXIN2

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical