Summary of ARNTL

ARNTL (aka BMAL1) increases functionality in the circadian clock. It is associated with major depressive disorders, heightened responses to antidepressants, and is a key component in the functionality of the bodys circadian clock [R]. Disruptions in the circadian rhythms contribute to cardiovascular diseases, cancer, metabolic syndromes and aging.

ARNTL/BMAL1 increases muscle production and decreases fat cell creation.

ARNTL plays an important role in adult hippocampal neurogenesis. Increases the expression of enzymes that increase hormonal production, and also the genes involved in hair growth.

ARNTL/BMAL1 has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity, and mutations in BMAL1 have been linked to infertility, gluconeogenesis and lipogenesis problems, and altered sleep patterns.

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Protein names

Recommended name:

Aryl hydrocarbon receptor nuclear translocator-like protein 1

Alternative name(s):

Basic-helix-loop-helix-PAS protein MOP3
Brain and muscle ARNT-like 1
Class E basic helix-loop-helix protein 5
Member of PAS protein 3
PAS domain-containing protein 3
bHLH-PAS protein JAP3

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Top Gene-Substance Interactions

ARNTL Interacts with These Diseases


Substances That Increase ARNTL

Substances That Decrease ARNTL

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity