The Function of ARNT

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

Protein names

Recommended name:

Aryl hydrocarbon receptor nuclear translocator

Alternative name(s):

ARNT protein
Class E basic helix-loop-helix protein 2
Dioxin receptor, nuclear translocator
Hypoxia-inducible factor 1-beta

Get a Grip on Your Health. Use SelfDecode to Interpret your Genome Today! GET INSTANT ACCESS

Top Gene-Substance Interactions

ARNT Interacts with These Diseases

Substances That Increase ARNT

Substances That Decrease ARNT

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity