Summary of APOB

The APOB gene encodes two versions of the apolipoprotein B protein and they carry fats and fat-like substances (such as cholesterol) in the blood. Apolipoprotein B-100 lets the fats and fat-like substances to attach to receptors on the surface of cells, then the receptors transport low-density lipoproteins into the cell, where they are broken down to release cholesterol. The cholesterol is then used by the cell, stored, or removed from the body (R). 

Mutations of this gene can cause high cholesterol and increase heart disease risk (R). 

The Function of APOB

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

Protein names

Recommended name:

Apolipoprotein B-100

Alternative name(s):

Apo B-100
Apo B-48

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Top Gene-Substance Interactions

APOB Interacts with These Diseases


Substances That Increase APOB

Substances That Decrease APOB

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity