The Function of ANXA2

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).

Protein names

Recommended name:

Annexin A2

Alternative name(s):

Annexin II
Calpactin I heavy chain
Calpactin-1 heavy chain
Lipocortin II
Placental anticoagulant protein IV
Protein I

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Top Gene-Substance Interactions

ANXA2 Interacts with These Diseases

Substances That Increase ANXA2

Substances That Decrease ANXA2

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity