Function

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.

Protein names

Recommended name:

AKT-interacting protein

Alternative name(s):

Ft1
Fused toes protein homolog

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Top Gene-Substance Interactions

AKTIP Interacts with These Diseases

Substances That Increase AKTIP

Substances That Decrease AKTIP

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical