The Function of AKT2

One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on 'Ser-197' during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Phosphorylates CLK2 on 'Thr-343'.

Protein names

Recommended name:

RAC-beta serine/threonine-protein kinase

Alternative name(s):

Protein kinase Akt-2
Protein kinase B beta
PKB beta

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Top Gene-Substance Interactions

AKT2 Interacts with These Diseases

Substances That Increase AKT2

Substances That Decrease AKT2

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity