Summary of AKT1

The AKT1 gene encodes for the serine-threonine protein kinase. AKT1 and the related AKT2 are activated by platelet-derived growth factor. It plays an important role in the nervous system as a mediator of growth factor-induced neuronal survival. It can suppress cell death (R). 

Mutations in this gene are associated with Proteus syndrome, which is an overgrowth of bones and organs (R). 


The Function of AKT1

AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.

Protein names

Recommended name:

RAC-alpha serine/threonine-protein kinase

Short name:

PKB

Alternative name(s):

Protein kinase B
Protein kinase B alpha
PKB alpha
Proto-oncogene c-Akt
RAC-PK-alpha

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Top Gene-Substance Interactions

AKT1 Interacts with These Diseases

Fixes

Substances That Increase AKT1

Substances That Decrease AKT1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical