Summary

The AKT1 gene encodes for the serine-threonine protein kinase. AKT1 and the related AKT2 are activated by platelet-derived growth factor. It plays an important role in the nervous system as a mediator of growth factor-induced neuronal survival. It can suppress cell death (R). 

Mutations in this gene are associated with Proteus syndrome, which is an overgrowth of bones and organs (R). 


Function

AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.

Protein names

Recommended name:

RAC-alpha serine/threonine-protein kinase

Short name:

PKB

Alternative name(s):

Protein kinase B
Protein kinase B alpha
PKB alpha
Proto-oncogene c-Akt
RAC-PK-alpha

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