Summary of AGT

The AGT gene encodes a protein called angiotensinogen which is part of the renin-angiotensin system. The system regulates blood pressure and the balance of fluids and salts in the body (R). 

Mutations can cause problems with the kidneys and also cause excessively high or low blood pressure (R). 

The Function of AGT

Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Protein names

Recommended name:


Alternative name(s):

Serpin A8
Angiotensin 1-10
Angiotensin I
Ang I
Angiotensin 1-8
Angiotensin II
Ang II
Angiotensin 2-8
Angiotensin III
Des-Asp[1]-angiotensin II
Angiotensin 3-8
Angiotensin IV
Ang IV

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Top Gene-Substance Interactions

AGT Interacts with These Diseases

Substances That Increase AGT

Substances That Decrease AGT

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity