Summary

The AGT gene encodes a protein called angiotensinogen which is part of the renin-angiotensin system. The system regulates blood pressure and the balance of fluids and salts in the body (R). 

Mutations can cause problems with the kidneys and also cause excessively high or low blood pressure (R). 


Function

Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

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