Summary of ADIPOQ

ADIPOQ encodes for the protein hormone Adiponectin, the hormone which burns fat [R]. ADIPOQ is involved in the breakdown of fatty acids and other metabolic processes (regulating glucose levels) [R]. Found explicitly in fat tissue, mutations of this gene are associated with a weakened ability to break down fatty acids [R].

This protein hormone helps suppress metabolic derangements which led to type 2 diabetes, obesity, atherosclerosis, non-alcoholic fatty liver disease, and low levels is an independent risk factor for metabolic syndrome [R].

Females have higher levels of adiponectin compared to males [R]. The concentration of adiponectin increases when calories are restricted such as in eating disorders [R].  

Levels of adiponectin are reduced in diabetics in comparison to non-diabetics [R].

Adiponectin may play a role in cell growth, the formation of new blood vessels, and tissue remodeling by binding and sequestering various growth factors [R].

Adiponectin stimulates AMPK, which is a pathway involved in increasing energy production [R, R2]. It also enhancing glucose utilization and fatty-acid combustion in the liver and the muscle [R].

Adiponectin reduces and blocks the effects of the inflammatory cytokine TNF-alpha [R, R2] and inhibits NF-Kappa-B [R].


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Protein names

Recommended name:

Adiponectin

Alternative name(s):

30 kDa adipocyte complement-related protein
Adipocyte complement-related 30 kDa protein
ACRP30
Adipocyte, C1q and collagen domain-containing protein
Adipose most abundant gene transcript 1 protein
apM-1
Gelatin-binding protein

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Top Gene-Substance Interactions

ADIPOQ Interacts with These Diseases

Fixes

Substances That Increase ADIPOQ

Substances That Decrease ADIPOQ

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical