The Function of ACOX1

Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.

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Top Gene-Substance Interactions

ACOX1 Interacts with These Diseases

Substances That Increase ACOX1

Substances That Decrease ACOX1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical