Summary of ACACB

This gene encodes for the acetyl-CoA carboxylase beta (ACACB) protein. This protein is important in allowing for fatty acid synthesis and also protects fatty acids from oxidation [R]. Mutations to the ACACB gene can cause an increased risk of type II Diabetes, metabolic syndrome, and obesity [R].


Function

Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1.

Protein names

Recommended name:

Acetyl-CoA carboxylase 2

Alternative name(s):

ACC-beta

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Top Gene-Substance Interactions

ACACB Interacts with These Diseases

Substances That Increase ACACB

Substances That Decrease ACACB

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical