Summary of ABCG8

The ABCG8 gene encodes sterolin-2, which makes up half of a protein called sterolin. Sterolin is involved in eliminating sterols, which are fatty components of plant-based foods that cannot be used by human cells. Sterolin also helps regulate levels of cholesterol (R).

Mutations can cause high cholesterol, anemia, and increase the risk of getting gallstones (R).

The Function of ABCG8

Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

Protein names

Recommended name:

ATP-binding cassette sub-family G member 8

Alternative name(s):


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Top Gene-Substance Interactions

ABCG8 Interacts with These Diseases

Substances That Increase ABCG8

Substances That Decrease ABCG8

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity