Summary of ABCC1

ABCC1 is part of a group of genes that transports molecules across cellular membranes (within and through cells) [R1]. This gene is involved in multidrug resistance [R2] and metabolism [R3]. It is also responsible for the transport of antiviral drugs and is affiliated with resistance to anticancer drugs [R4].

Also known as multidrug resistance protein 1 (MRP1).

The Function of ABCC1

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

Protein names

Recommended name:

Multidrug resistance-associated protein 1

Alternative name(s):

ATP-binding cassette sub-family C member 1
Leukotriene C(4
LTC4 transporter

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Top Gene-Substance Interactions

ABCC1 Interacts with These Diseases


Substances That Increase ABCC1

Substances That Decrease ABCC1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity