Summary

ABCB1 encodes proteins that transport various molecules across extra- and intra-cellular membranes. It is involved in multidrug resistance and also helps as a transporter in the blood brain barrier (R). 

It is associated with warfarin resistance and bowel diseases (R).


It's better to have this gene increased most of the time. Exceptions: Chemotherapy

Function

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Protein names

Recommended name:

Multidrug resistance protein 1

Alternative name(s):

ATP-binding cassette sub-family B member 1
P-glycoprotein 1
CD antigen CD243

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