Summary of UGT1A1

The UGT1A1 gene encodes enzymes called UDP-glucuronosyltransferases. They perform glucuronidation, which is when glucuronic acid is attached to a different substance. Mutations are associated with warfarin resistance and jaundice in newborns (R). 


The Function of UGT1A1

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Protein names

Recommended name:

UDP-glucuronosyltransferase 1-1

Short name:

UGT1A

Alternative name(s):

UDPGT 1-1
UGT1*1
UGT1-01
UGT1.1
Bilirubin-specific UDPGT isozyme 1
hUG-BR1
UDP-glucuronosyltransferase 1-A
UGT-1A
UDP-glucuronosyltransferase 1A1

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Top Gene-Substance Interactions

UGT1A1 Interacts with These Diseases

Substances That Increase UGT1A1

Substances That Decrease UGT1A1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical