Summary of IRS1

IRS-1 plays important biological function for both metabolic and growth promoting pathways. IRS-1 may also play a role in cancer, as it has been shown that mice with overproduction of IRS-1 develop breast cancer. (R) Lower levels of IRS1 cause insulin resistance. IRS1 is needed for cells to take up insulin. (Ref)


The Function of IRS1

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Protein names

Recommended name:

Insulin receptor substrate 1

Short name:

IRS-1

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Top Gene-Substance Interactions

IRS1 Interacts with These Diseases

Substances That Increase IRS1

Substances That Decrease IRS1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical