Summary

IL12A (interleukin 12A) encodes for a protein that acts on T and natural killer cells. It is required for the T-cell-independent induction of interferon (IFN)-gamma and is important for the differentiation of Th1 and Th2 cells (R).

Interleukin-12 is primarily a cytokine that is immune stimulatory and increases the Th1 immune system.


Function

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.

Protein names

Recommended name:

Interleukin-12 subunit alpha

Short name:

NKSF1

Alternative name(s):

IL-12A
Cytotoxic lymphocyte maturation factor 35 kDa subunit
CLMF p35
IL-12 subunit p35
NK cell stimulatory factor chain 1

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