Summary of ICAM1

This gene encodes a glycoprotein that is expressed in immune system cells, ICAM-1.  ICAM-1 is a molecule that attracts immune cells and help them to migrate through blood vessels into tissues. ICAM-1 is important for an effective immune response, but it can also sustain chronic inflammation.


It's better to have this gene decreased most of the time. Exceptions: IMMUNE SUPPRESSION, Immune Deficiency Disease, Immune Deficiency, Familial Variable, Immune dysfunction with T-cell inactivation due to calcium entry defect 1
0 user want this gene increased, 0 users want it decreased

The Function of ICAM1

(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243). Acts as a receptor for Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703). Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell (PubMed:11413168).

Protein names

Recommended name:

Intercellular adhesion molecule 1

Short name:

ICAM-1

Alternative name(s):

Major group rhinovirus receptor
CD antigen CD54

Get a Grip on Your Health. Use SelfDecode to Interpret your Genome Today! GET INSTANT ACCESS

Top Gene-Substance Interactions

ICAM1 Interacts with These Diseases

Substances That Increase ICAM1

Substances That Decrease ICAM1

Advanced Summary

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical