Summary of CYP2D6

CYP2D6 is responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.

The CYP2D6 enzymes metabolize about 25% of pharmaceutical drugs such as SSRIs, opioids, tamoxifen, Nyquil, and beta blockers.  

It also metabolizes serotonin and neurosteroids (pregnenolone, cholesterol, androsterone, etc). There are several important polymorphisms in CYP2D6 which cause either extensive or very poor metabolism “ or something in between.  

There are both good and bad potential consequences from being a poor or extensive metabolizer. Being a poor metabolizer may reduce the risk of some cancers such as bladder or lung.  

On the other hand, it also may significantly increase the risk of Parkinson's disease for those exposed to pesticides.  Knowing whether you're a fast or slow metabolizer may make it easier to find the right dosage of certain medications.

Protein names

Recommended name:

Cytochrome P450 2D6

Short name:


Alternative name(s):

Cholesterol 25-hydroxylase
Cytochrome P450-DB1
Debrisoquine 4-hydroxylase

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Top Gene-Substance Interactions

CYP2D6 Interacts with These Diseases

Substances That Increase CYP2D6

Substances That Decrease CYP2D6

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity