The CAT gene encodes pieces (subunits) of an enzyme called catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. 

Catalase breaks down hydrogen peroxide (H2O2) molecules into oxygen (O2) and water (H2O) and thereby mitigates the toxic effects of hydrogen peroxide; high levels of catalase is toxic to cells (R, R). 

Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells.

It's better to have this gene increased most of the time.


Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.

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