Top Gene Interactions
- Metabolism: Hepatic. Metabolism of vinblastine has been shown to be mediated by hepatic cytochrome P450 3A isoenzymes. Route of Elimination: The major route of excretion may be through the biliary system. Half Life: Triphasic: 35 min, 53 min, and 19 hours
- Uses/Sources: For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: Oral, mouse: LD<sub>50</sub> = 423 mg/kg; Oral, rat: LD<sub>50</sub> = 305 mg/kg.
Mechanism of Action
|Target Name||Mechanism of Action||References|
Tubulin beta chain
Tubulin gamma-1 chain
Tubulin alpha-1A chain
Tubulin delta chain
Tubulin epsilon chain
Transcription factor AP-1