Definition

Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)

Description

Vinblastine is only found in individuals that have used or taken this drug. It is an antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)The antitumor activity of vinblastine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Vinblastine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.

Top Gene Interactions

Related Pathways

General Information

Toxicity

Mechanism of Action

Vinblastine Interacts with Diseases

Vinblastine Interacts with Genes