- Metabolism: Almost none of the compound is metabolized.
- Uses/Sources: For the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults.
- Route of Exposure: Poorly absorbed from the gastrointestinal tract. Well absorbed following intramuscular injection.
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: Inadvertent administration of 5 times the recommended dose, infused intravenously over a 24 hour period, to an asymptomatic 16 month old patient with a blood lead content of 56 mcg/dl did not cause any ill effects. Edetate calcium disodium can aggravate the symptoms of severe lead poisoning, therefore, most toxic effects (cerebral edema, renal tubular necrosis) appear to be associated with lead poisoning. Because of cerebral edema, a therapeutic dose may be lethal to an adult or a pediatric patient with lead encephalopathy. Higher dosage of edetate calcium disodium may produce a more severe zinc deficiency.
Mechanism of Action
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