Top Gene Interactions
- Metabolism: Hepatic.
- Uses/Sources: For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli.
- Health Effects: They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive. They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive.
- Symptoms: Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
- Route of Exposure: Oral
Mechanism of Action
|Target Name||Mechanism of Action||References|
Gamma-aminobutyric acid receptor subunit alpha-2
Gamma-aminobutyric acid receptor subunit alpha-3
Gamma-aminobutyric acid receptor subunit alpha-4
Gamma-aminobutyric acid receptor subunit alpha-5
Gamma-aminobutyric acid receptor subunit alpha-6
Neuronal acetylcholine receptor subunit alpha-4
Neuronal acetylcholine receptor subunit alpha-7
Glutamate receptor 2
Glutamate receptor ionotropic, kainate 2
Gamma-aminobutyric acid receptor subunit alpha-1
Methyl-CpG-binding domain protein 2
|Hexobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.||
Hexobarbital Interacts with Diseases
|Disease||Inference Score||References/Inference Genes|
|Generalized Epilepsy With Febrile Seizures Plus, Type 3||7.69||
|Drug Metabolism, Poor, CYP2C19-Related||7.4|
|Generalized Epilepsy With Febrile Seizures Plus, Type 1||7.0||
|Primary ovarian insufficiency||6.2||
|Kidney Failure, Chronic||4.91||
|Torsades de pointes||4.3||
|Acute kidney injury||4.21||
|Drug-induced liver injury||3.82||