GLYCYRRHETINIC ACID | SelfDecode | Genome Analysis

Glycyrrhetinic Acid

Potential Recommendations, Possibly Consumable Substances, Substances of Biological Interest

Definition

An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation. Aglycone from licorice (Glycyrrhiza glabra) Glycyrrhetinic acid is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice. It is used in flavoring and it masks the bitter taste of drugs like aloe and quinine. (Wikipedia)

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Top Gene Interactions

Related Pathways

Glycyrrhetinic Acid Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Pulmonary Fibrosis	19.95	References/Inference Genes References Inference genes 23640035 19684199 17894541 23570914 15298984 17266442 CAT CSF2 IL1B NFE2L2 SOD3
Heart failure	18.94	References/Inference Genes References Inference genes 16105639 11732872 1647690 20304815 7034517 20811386 11771600 15135663 ALB CAT CSF2 IL1B REN SOD3
Cell Transformation, Neoplastic	17.14	References/Inference Genes References Inference genes 18829283 23518002 23877152 21742780 22048643 18245498 19696165 20516118 25448439 AKR1C1 AKR1C3 CAT HRAS
Drug-Related Side Effects and Adverse Reactions	16.93	References/Inference Genes References Inference genes 20605904 10445756 18990727 8723173 24361871 7960606 ALB CSF2 CYP1A2 CYP2E1 NFE2L2 REN
Neoplasms, Hormone-Dependent	16.64	References/Inference Genes References Inference genes 25304492 AKR1C1 AKR1C3
Psoriasis	15.84	References/Inference Genes References Inference genes 7744320 12559600 3540694 CAT CSF2 IL1B REN
Disorders of Sex Development	15.38	References/Inference Genes References Inference genes 25304492 AKR1C1 AKR1C3
Polycystic ovary syndrome	15.04	References/Inference Genes References Inference genes 21262361 22381227 16263811 AKR1C1 AKR1C3 HSD3B1
Carcinoma, Non-Small-Cell Lung	14.52	References/Inference Genes References Inference genes 22684020 26482881 11731445 17094902 16142352 AKR1C1 CAT CYP2E1 NFE2L2
Liver Cirrhosis, Experimental	14.2	References/Inference Genes References Inference genes 16642209 23341968 21163135 17963606 16085334 17072980 25380136 AKR1C1 AKR1C3 ALB CYP1A2 IL1B NFE2L2
Hypertension	14.07	References/Inference Genes References Inference genes 1071603 2526952 11479740 21593737 45830 998518 7721401 12600921 20811386 19770776 1149188 22228705 18847324 6381767 20429690 18679781 27292124 12414515 20667508 17023265 11501062 21393355 62162 17537837 16864745 ALB CAT IL1B REN SOD3
Liver Cirrhosis	13.49	References/Inference Genes References Inference genes 17977396 15613622 23793039 21851314 ALB NFE2L2 REN
Drug-induced liver injury	12.48	References/Inference Genes References Inference genes 16770646 18779383 21741958 22310181 22491424 24813929 22627062 20623750 12668988 26958860 11529661 19164858 ALB CAT CYP2E1 IL1B NFE2L2 SOD3
Non-alcoholic fatty liver disease	12.01	References/Inference Genes References Inference genes 25294219 21664615 26428356 CSF2 CYP2E1 NFE2L2
Endometrial neoplasm	11.93	References/Inference Genes References Inference genes 20530669 16338060 AKR1C1 AKR1C3 NFE2L2
Necrosis	11.85	References/Inference Genes References Inference genes 17309078 12086689 10631206 12566070 10903806 24813929 11529661 9548797 10909967 CAT CYP2E1 IL1B NFE2L2 SOD3
Thyroid carcinoma	11.82	References/Inference Genes References Inference genes 26037280 3078959 CSF2 HRAS IL1B
Breast carcinoma	11.59	References/Inference Genes References Inference genes 16298037 11325840 17474063 15958052 12165863 17516992 25322848 19652463 CAT CSF2 HRAS IL1B
Liver Neoplasms	11.35	References/Inference Genes References Inference genes 10874023 17093202 17326190 17514646 20722399 16410370 12127263 12082015 CSF2 CYP2E1 HRAS NFE2L2
Stomach Neoplasms	11.33	References/Inference Genes References Inference genes 19584167 15492468 19424620 26558449 11397402 22414649 AKR1C3 ALB HRAS IL1B

Glycyrrhetinic Acid Interacts with Genes

Interaction	References
Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein]	R

Interaction	References
Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]	R

Interaction	References
Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]	R

Interaction	References
[brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein	R

Interaction	References
Glycyrrhetinic Acid binds to ALB protein	R

Interaction	References
[brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP1A2 protein	R

Interaction	References
Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD3 mRNA]	R

Interaction	References
[Glycyrrhetinic Acid co-treated with NADP] binds to HSD3B1 protein	R

Interaction	References
Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]	R

Interaction	References
Glycyrrhetinic Acid results in decreased activity of REN protein	R