GLYCYRRHETINIC ACID | SelfDecode | Genome Analysis

Glycyrrhetinic Acid

Potential Recommendations, Possibly Consumable Substances, Substances of Biological Interest

Definition

An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation. Aglycone from licorice (Glycyrrhiza glabra) Glycyrrhetinic acid is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice. It is used in flavoring and it masks the bitter taste of drugs like aloe and quinine. (Wikipedia)

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Top Gene Interactions

Related Pathways

Glycyrrhetinic Acid Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Pulmonary Fibrosis	19.95	References/Inference Genes References Inference genes 19684199 15298984 17894541 17266442 23570914 23640035 CAT CSF2 IL1B NFE2L2 SOD3
Heart failure	18.94	References/Inference Genes References Inference genes 1647690 20304815 11771600 15135663 16105639 20811386 7034517 11732872 ALB CAT CSF2 IL1B REN SOD3
Cell Transformation, Neoplastic	17.14	References/Inference Genes References Inference genes 22048643 25448439 23518002 18245498 18829283 23877152 20516118 21742780 19696165 AKR1C1 AKR1C3 CAT HRAS
Drug-Related Side Effects and Adverse Reactions	16.93	References/Inference Genes References Inference genes 18990727 24361871 10445756 20605904 8723173 7960606 ALB CSF2 CYP1A2 CYP2E1 NFE2L2 REN
Neoplasms, Hormone-Dependent	16.64	References/Inference Genes References Inference genes 25304492 AKR1C1 AKR1C3
Psoriasis	15.84	References/Inference Genes References Inference genes 12559600 7744320 3540694 CAT CSF2 IL1B REN
Disorders of Sex Development	15.38	References/Inference Genes References Inference genes 25304492 AKR1C1 AKR1C3
Polycystic ovary syndrome	15.04	References/Inference Genes References Inference genes 22381227 21262361 16263811 AKR1C1 AKR1C3 HSD3B1
Carcinoma, Non-Small-Cell Lung	14.52	References/Inference Genes References Inference genes 16142352 26482881 17094902 11731445 22684020 AKR1C1 CAT CYP2E1 NFE2L2
Liver Cirrhosis, Experimental	14.2	References/Inference Genes References Inference genes 21163135 17963606 25380136 17072980 16085334 23341968 16642209 AKR1C1 AKR1C3 ALB CYP1A2 IL1B NFE2L2
Hypertension	14.07	References/Inference Genes References Inference genes 18679781 18847324 21393355 16864745 17023265 22228705 998518 1149188 20811386 20429690 21593737 2526952 17537837 45830 6381767 12414515 11479740 20667508 12600921 1071603 62162 7721401 19770776 11501062 27292124 ALB CAT IL1B REN SOD3
Liver Cirrhosis	13.49	References/Inference Genes References Inference genes 17977396 23793039 21851314 15613622 ALB NFE2L2 REN
Drug-induced liver injury	12.48	References/Inference Genes References Inference genes 21741958 22310181 11529661 22491424 12668988 20623750 18779383 24813929 22627062 19164858 26958860 16770646 ALB CAT CYP2E1 IL1B NFE2L2 SOD3
Non-alcoholic fatty liver disease	12.01	References/Inference Genes References Inference genes 25294219 26428356 21664615 CSF2 CYP2E1 NFE2L2
Endometrial neoplasm	11.93	References/Inference Genes References Inference genes 16338060 20530669 AKR1C1 AKR1C3 NFE2L2
Necrosis	11.85	References/Inference Genes References Inference genes 17309078 11529661 12566070 10631206 12086689 10909967 10903806 24813929 9548797 CAT CYP2E1 IL1B NFE2L2 SOD3
Thyroid carcinoma	11.82	References/Inference Genes References Inference genes 3078959 26037280 CSF2 HRAS IL1B
Breast carcinoma	11.59	References/Inference Genes References Inference genes 11325840 17516992 16298037 15958052 19652463 17474063 25322848 12165863 CAT CSF2 HRAS IL1B
Liver Neoplasms	11.35	References/Inference Genes References Inference genes 17326190 10874023 20722399 17093202 16410370 17514646 12082015 12127263 CSF2 CYP2E1 HRAS NFE2L2
Stomach Neoplasms	11.33	References/Inference Genes References Inference genes 22414649 19584167 15492468 26558449 19424620 11397402 AKR1C3 ALB HRAS IL1B

Glycyrrhetinic Acid Interacts with Genes

Interaction	References
Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein]	R

Interaction	References
Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]	R

Interaction	References
Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]	R

Interaction	References
[brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein	R

Interaction	References
Glycyrrhetinic Acid binds to ALB protein	R

Interaction	References
[brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP1A2 protein	R

Interaction	References
Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD3 mRNA]	R

Interaction	References
[Glycyrrhetinic Acid co-treated with NADP] binds to HSD3B1 protein	R

Interaction	References
Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]	R

Interaction	References
Glycyrrhetinic Acid results in decreased activity of REN protein	R