GLYCYRRHETINIC ACID | SelfDecode | Genome Analysis

Glycyrrhetinic Acid

Potential Recommendations, Possibly Consumable Substances, Substances of Biological Interest

Definition

An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation. Aglycone from licorice (Glycyrrhiza glabra) Glycyrrhetinic acid is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice. It is used in flavoring and it masks the bitter taste of drugs like aloe and quinine. (Wikipedia)

Top Gene Interactions

Related Pathways

Glycyrrhetinic Acid Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Pulmonary Fibrosis	19.95	References/Inference Genes References Inference genes 17894541 23570914 15298984 23640035 17266442 19684199 CAT CSF2 IL1B NFE2L2 SOD3
Heart failure	18.94	References/Inference Genes References Inference genes 20304815 7034517 16105639 11771600 15135663 20811386 11732872 1647690 ALB CAT CSF2 IL1B REN SOD3
Cell Transformation, Neoplastic	17.14	References/Inference Genes References Inference genes 23518002 23877152 18829283 18245498 22048643 21742780 25448439 20516118 19696165 AKR1C1 AKR1C3 CAT HRAS
Drug-Related Side Effects and Adverse Reactions	16.93	References/Inference Genes References Inference genes 18990727 8723173 24361871 20605904 10445756 7960606 ALB CSF2 CYP1A2 CYP2E1 NFE2L2 REN
Neoplasms, Hormone-Dependent	16.64	References/Inference Genes References Inference genes 25304492 AKR1C1 AKR1C3
Psoriasis	15.84	References/Inference Genes References Inference genes 7744320 12559600 3540694 CAT CSF2 IL1B REN
Disorders of Sex Development	15.38	References/Inference Genes References Inference genes 25304492 AKR1C1 AKR1C3
Polycystic ovary syndrome	15.04	References/Inference Genes References Inference genes 16263811 22381227 21262361 AKR1C1 AKR1C3 HSD3B1
Carcinoma, Non-Small-Cell Lung	14.52	References/Inference Genes References Inference genes 22684020 26482881 11731445 16142352 17094902 AKR1C1 CAT CYP2E1 NFE2L2
Liver Cirrhosis, Experimental	14.2	References/Inference Genes References Inference genes 16085334 17072980 16642209 17963606 25380136 23341968 21163135 AKR1C1 AKR1C3 ALB CYP1A2 IL1B NFE2L2
Hypertension	14.07	References/Inference Genes References Inference genes 22228705 16864745 20667508 11501062 998518 17023265 6381767 12600921 20429690 7721401 12414515 27292124 1149188 19770776 45830 17537837 62162 21593737 2526952 1071603 18679781 11479740 20811386 21393355 18847324 ALB CAT IL1B REN SOD3
Liver Cirrhosis	13.49	References/Inference Genes References Inference genes 21851314 17977396 23793039 15613622 ALB NFE2L2 REN
Drug-induced liver injury	12.48	References/Inference Genes References Inference genes 18779383 11529661 24813929 21741958 20623750 22310181 12668988 22627062 19164858 16770646 26958860 22491424 ALB CAT CYP2E1 IL1B NFE2L2 SOD3
Non-alcoholic fatty liver disease	12.01	References/Inference Genes References Inference genes 21664615 25294219 26428356 CSF2 CYP2E1 NFE2L2
Endometrial neoplasm	11.93	References/Inference Genes References Inference genes 16338060 20530669 AKR1C1 AKR1C3 NFE2L2
Necrosis	11.85	References/Inference Genes References Inference genes 9548797 11529661 24813929 10909967 10631206 17309078 12086689 12566070 10903806 CAT CYP2E1 IL1B NFE2L2 SOD3
Thyroid carcinoma	11.82	References/Inference Genes References Inference genes 26037280 3078959 CSF2 HRAS IL1B
Breast carcinoma	11.59	References/Inference Genes References Inference genes 19652463 25322848 12165863 15958052 17474063 16298037 17516992 11325840 CAT CSF2 HRAS IL1B
Liver Neoplasms	11.35	References/Inference Genes References Inference genes 12082015 17326190 20722399 10874023 17514646 16410370 17093202 12127263 CSF2 CYP2E1 HRAS NFE2L2
Stomach Neoplasms	11.33	References/Inference Genes References Inference genes 22414649 15492468 19424620 26558449 11397402 19584167 AKR1C3 ALB HRAS IL1B

Glycyrrhetinic Acid Interacts with Genes

Interaction	References
Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein]	R

Interaction	References
Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]	R

Interaction	References
Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]	R

Interaction	References
[brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein	R

Interaction	References
Glycyrrhetinic Acid binds to ALB protein	R

Interaction	References
[brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP1A2 protein	R

Interaction	References
Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD3 mRNA]	R

Interaction	References
[Glycyrrhetinic Acid co-treated with NADP] binds to HSD3B1 protein	R

Interaction	References
Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]	R

Interaction	References
Glycyrrhetinic Acid results in decreased activity of REN protein	R