Top Gene Interactions
- Metabolism: Hepatic. Extensively metabolized - after oral administration, less than 5% of the administered dose can be recovered in the active form in the urine. Erythromycin is partially metabolized by CYP3A4 resulting in numerous drug interactions. Half Life: 0.8 - 3 hours
- Uses/Sources: For use in the treatment of infections caused by susceptible strains of microorganisms in the following diseases: respiratory tract infections (upper and lower) of mild to moderate degree, pertussis (whooping cough), as adjunct to antitoxin in infections due to Corynebacterium diphtheriae, in the treatment of infections due to Corynebacterium minutissimum, intestinal amebiasis caused by Entamoeba histolytica, acute pelvic inflammatory disease caused by Neisseria gonorrhoeae, skin and soft tissue infections of mild to moderate severity caused by Streptococcus pyogenes and Staphylococcus aureus, primary syphilis caused by Treponema pallidum, infections caused by Chlamydia trachomatis, nongonococcal urethritis caused by Ureaplasma urealyticum, and Legionnaires' disease caused by Legionella pneumophila.
- Symptoms: Symptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting.
- Route of Exposure: Orally administered erythromycin base and its salts are readily absorbed in the microbiologically active form. Topical application of the ophthalmic ointment to the eye may result in absorption into the cornea and aqueous humor.
Mechanism of Action
|Target Name||Mechanism of Action||References|
Erythromycin Interacts with Diseases
|Disease||Inference Score||References/Inference Genes|
|Kidney Failure, Chronic||32.23|
|Diabetes Mellitus, Experimental||23.63|
|Drug-induced liver injury||18.37||
|Liver Cirrhosis, Experimental||18.25|
|PLASMODIUM FALCIPARUM BLOOD INFECTION LEVEL||15.41|