ERYTHROMYCIN

Definition

A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

Description

Erythromycin is a macrolide antibiotic produced by Streptomyces erythreus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits; binding inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.

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General Information

Metabolism: Hepatic. Extensively metabolized - after oral administration, less than 5% of the administered dose can be recovered in the active form in the urine. Erythromycin is partially metabolized by CYP3A4 resulting in numerous drug interactions. Half Life: 0.8 - 3 hours
Uses/Sources: For use in the treatment of infections caused by susceptible strains of microorganisms in the following diseases: respiratory tract infections (upper and lower) of mild to moderate degree, pertussis (whooping cough), as adjunct to antitoxin in infections due to Corynebacterium diphtheriae, in the treatment of infections due to Corynebacterium minutissimum, intestinal amebiasis caused by Entamoeba histolytica, acute pelvic inflammatory disease caused by Neisseria gonorrhoeae, skin and soft tissue infections of mild to moderate severity caused by Streptococcus pyogenes and Staphylococcus aureus, primary syphilis caused by Treponema pallidum, infections caused by Chlamydia trachomatis, nongonococcal urethritis caused by Ureaplasma urealyticum, and Legionnaires' disease caused by Legionella pneumophila.
Symptoms: Symptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting.
Route of Exposure: Orally administered erythromycin base and its salts are readily absorbed in the microbiologically active form. Topical application of the ophthalmic ointment to the eye may result in absorption into the cornea and aqueous humor.

Mechanism of Action

Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the “P” or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the “A” or acceptor site to the “P” or donor site is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not fully known: however, the effect appears to be due in part to the antibacterial activity of the drug.

Target Name	Mechanism of Action	References
Estrogen receptor		23611293

Erythromycin Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Lipidoses	43.55	References/Inference Genes References Inference genes 15342952 16919414 17175557 ASAH1 ASNS FNDC4 HPN INHBE NUPR1 TAGLN
Kidney Failure, Chronic	32.23	References/Inference Genes References Inference genes 16518626 19420110 22622455 19539174 19878707 CAT CCL2 CPT1A CRP HMOX1 IL6 NFKB1 SREBF1 TNF
Reperfusion Injury	30.79	References/Inference Genes References Inference genes 10706834 17906103 23743330 8215636 16971220 12024109 23875703 12352873 11557319 12865660 23075401 17660127 16526316 27064547 15829914 25780291 21940958 18258783 17032661 16682413 12468449 18460982 17112405 19058328 16982915 19673871 CAT CCL2 CD36 CXCL8 HMOX1 ICAM1 IL1A IL6 SELE TLR4 TNF
Obesity	27.91	References/Inference Genes References Inference genes 20141834 10900012 20882379 11782876 19171794 18334666 18375438 11328671 17405841 24042701 9502777 23349936 CRP CS HMOX1 ICAM1 IL6 LBP NQO1 SREBF1 TNF
Atherosclerosis	23.88	References/Inference Genes References Inference genes 9169506 19330073 12928151 12124407 20720404 12677255 16931792 25020133 CCL2 CRP HRH1 ICAM1 IFNG IL6 TLR4 TNF VCAM1
Diabetes Mellitus, Experimental	23.63	References/Inference Genes References Inference genes 12193562 10900012 23458895 15855331 21340626 24513509 9452481 16959961 20388520 16123366 23090186 19478208 18375438 19804535 12123627 20709041 22138235 14871415 CAT CPT1A GPAM HMOX1 ICAM1 IFNG IL6 NQO1 SREBF1 TNF
Visceral leishmaniasis	22.29	References/Inference Genes References Inference genes 7554475 7854095 1901333 17404324 10467834 22461696 CRP CXCL8 HMOX1 IFNG IL6 TNF
Myocardial Ischemia	22.0	References/Inference Genes References Inference genes 16214533 11840375 16286589 16775501 CCL2 CD36 CRP HMOX1 ICAM1 IL1A IL6 SELE TNF VCAM1
Hepatocellular carcinoma	21.86	References/Inference Genes References Inference genes 22922871 17510421 21147110 22561517 19363144 12432545 20818158 14563831 27022031 17615358 ABCB1 ACACA CRP CXCL8 IL6 NFE2L2 SREBF1 TLR4 TNF VCAM1
Pulmonary Fibrosis	20.38	References/Inference Genes References Inference genes 15814490 17720292 17266442 17894541 11394717 14609568 26163174 23570914 16324872 19684199 26368622 25216247 CAT CCL2 CCR2 CXCL8 HMOX1 IL6 NFE2L2 TNF
Heart failure	20.3	References/Inference Genes References Inference genes 15231041 3091246 26670611 22352330 16360360 15135663 8922916 18034274 17337591 16105639 20938210 ACACA CAT CRP CS HMOX1 IFNG IL6 TNF
Prostatic Neoplasms	19.27	References/Inference Genes References Inference genes 17507624 25970160 25246272 19240160 15583422 20124447 17196171 16606632 16783571 17013881 25735316 23441843 17301271 19011039 15496535 17606477 18306354 15672864 CXCL8 CYP11B2 CYP3A4 CYP3A5 DEFB1 HMOX1 HPN ICAM1 IL6 NFE2L2 NQO1 TLR4
Brain Ischemia	19.12	References/Inference Genes References Inference genes 19417757 15756928 17394460 18628779 15829914 17564305 CAT CCL2 ICAM1 IL1A IL6 NFKB1 SELE TNF
Crohn's disease	18.92	References/Inference Genes References Inference genes 11339241 17914947 10700533 21829567 CCL2 CRP IFNG IL6 TLR4 TNF
Drug-induced liver injury	18.37	References/Inference Genes References Inference genes 22627062 22688006 14971821 8218930 9696492 17984051 21570397 21741958 25226513 19483685 7532385 21245496 22491424 17709330 20623750 24813929 15763341 19638433 26958860 12153990 18227147 21984482 ABCB1 CAT CCL2 CCR2 CYP2C9 DGAT2 HLA-A HLA-B HMOX1 IFNG IL1A IL6 LBP NFE2L2 TNF
Liver Cirrhosis, Experimental	18.25	References/Inference Genes References Inference genes 17347453 16085334 17072980 25380136 12389079 21163135 15996030 16025519 15492853 16953842 16610050 23341968 ABCB1 ASAH1 ASNS CCL2 CD36 GPAM HMOX1 IFNG INHBE LBP NFE2L2 SREBF1 TLR4 TNF
Breast carcinoma	17.3	References/Inference Genes References Inference genes 25322848 18511948 17516992 15496535 25151356 22311042 16298037 25753200 19435922 19446661 ABCB1 CAT CPT1A CXCL8 CXCR4 CYP3A4 HMOX1 IFNG IL6 NQO1 TNF
Rheumatoid arthritis	16.31	References/Inference Genes References Inference genes 1568518 12566094 2001072 19192274 22104130 22450443 8391952 20080907 17379860 ABCB1 CAT CRP CXCL8 CXCR4 IFNG IL6 TNF
PLASMODIUM FALCIPARUM BLOOD INFECTION LEVEL	15.41	References/Inference Genes References Inference genes CD36 ICAM1 TNF
Arthritis, Experimental	14.92	References/Inference Genes References Inference genes 19203382 7589090 19330884 9598899 17827786 20974942 22450443 21452922 19765281 20131233 ABCB1 CAT CRP IFNG IL6 TNF

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Erythromycin

Definition

Description

Top Gene Interactions

Related Pathways

General Information

Mechanism of Action

Erythromycin Interacts with Diseases

Erythromycin Interacts with Genes

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