ERYTHROMYCIN

Definition

A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

Description

Erythromycin is a macrolide antibiotic produced by Streptomyces erythreus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits; binding inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.

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General Information

Metabolism: Hepatic. Extensively metabolized - after oral administration, less than 5% of the administered dose can be recovered in the active form in the urine. Erythromycin is partially metabolized by CYP3A4 resulting in numerous drug interactions. Half Life: 0.8 - 3 hours
Uses/Sources: For use in the treatment of infections caused by susceptible strains of microorganisms in the following diseases: respiratory tract infections (upper and lower) of mild to moderate degree, pertussis (whooping cough), as adjunct to antitoxin in infections due to Corynebacterium diphtheriae, in the treatment of infections due to Corynebacterium minutissimum, intestinal amebiasis caused by Entamoeba histolytica, acute pelvic inflammatory disease caused by Neisseria gonorrhoeae, skin and soft tissue infections of mild to moderate severity caused by Streptococcus pyogenes and Staphylococcus aureus, primary syphilis caused by Treponema pallidum, infections caused by Chlamydia trachomatis, nongonococcal urethritis caused by Ureaplasma urealyticum, and Legionnaires' disease caused by Legionella pneumophila.
Symptoms: Symptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting.
Route of Exposure: Orally administered erythromycin base and its salts are readily absorbed in the microbiologically active form. Topical application of the ophthalmic ointment to the eye may result in absorption into the cornea and aqueous humor.

Mechanism of Action

Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the “P” or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the “A” or acceptor site to the “P” or donor site is prevented, and subsequent protein synthesis is inhibited. Erythromycin is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not fully known: however, the effect appears to be due in part to the antibacterial activity of the drug.

Target Name	Mechanism of Action	References
Estrogen receptor		23611293

Erythromycin Interacts with Diseases

Disease	Inference Score	References/Inference Genes
Lipidoses	43.55	References/Inference Genes References Inference genes 17175557 15342952 16919414 ASAH1 ASNS FNDC4 HPN INHBE NUPR1 TAGLN
Kidney Failure, Chronic	32.23	References/Inference Genes References Inference genes 19420110 22622455 19878707 16518626 19539174 CAT CCL2 CPT1A CRP HMOX1 IL6 NFKB1 SREBF1 TNF
Reperfusion Injury	30.79	References/Inference Genes References Inference genes 12352873 23743330 16971220 12468449 8215636 19673871 23875703 15829914 23075401 17660127 19058328 25780291 16982915 18460982 17032661 21940958 16682413 12865660 18258783 17906103 27064547 12024109 10706834 17112405 16526316 11557319 CAT CCL2 CD36 CXCL8 HMOX1 ICAM1 IL1A IL6 SELE TLR4 TNF
Obesity	27.91	References/Inference Genes References Inference genes 9502777 20141834 11782876 18334666 23349936 20882379 17405841 18375438 11328671 10900012 19171794 24042701 CRP CS HMOX1 ICAM1 IL6 LBP NQO1 SREBF1 TNF
Atherosclerosis	23.88	References/Inference Genes References Inference genes 12677255 20720404 12124407 9169506 12928151 19330073 25020133 16931792 CCL2 CRP HRH1 ICAM1 IFNG IL6 TLR4 TNF VCAM1
Diabetes Mellitus, Experimental	23.63	References/Inference Genes References Inference genes 12123627 9452481 14871415 16959961 21340626 15855331 23458895 16123366 24513509 18375438 19804535 20709041 22138235 10900012 19478208 20388520 23090186 12193562 CAT CPT1A GPAM HMOX1 ICAM1 IFNG IL6 NQO1 SREBF1 TNF
Visceral leishmaniasis	22.29	References/Inference Genes References Inference genes 1901333 22461696 17404324 7854095 7554475 10467834 CRP CXCL8 HMOX1 IFNG IL6 TNF
Myocardial Ischemia	22.0	References/Inference Genes References Inference genes 11840375 16775501 16214533 16286589 CCL2 CD36 CRP HMOX1 ICAM1 IL1A IL6 SELE TNF VCAM1
Hepatocellular carcinoma	21.86	References/Inference Genes References Inference genes 27022031 12432545 22561517 20818158 21147110 19363144 17510421 14563831 22922871 17615358 ABCB1 ACACA CRP CXCL8 IL6 NFE2L2 SREBF1 TLR4 TNF VCAM1
Pulmonary Fibrosis	20.38	References/Inference Genes References Inference genes 23570914 16324872 14609568 26368622 17720292 26163174 25216247 15814490 11394717 19684199 17894541 17266442 CAT CCL2 CCR2 CXCL8 HMOX1 IL6 NFE2L2 TNF
Heart failure	20.3	References/Inference Genes References Inference genes 17337591 3091246 16105639 18034274 15135663 20938210 8922916 16360360 22352330 26670611 15231041 ACACA CAT CRP CS HMOX1 IFNG IL6 TNF
Prostatic Neoplasms	19.27	References/Inference Genes References Inference genes 18306354 25970160 17507624 25246272 19011039 19240160 15672864 17196171 20124447 25735316 17013881 16783571 17606477 16606632 17301271 23441843 15496535 15583422 CXCL8 CYP11B2 CYP3A4 CYP3A5 DEFB1 HMOX1 HPN ICAM1 IL6 NFE2L2 NQO1 TLR4
Brain Ischemia	19.12	References/Inference Genes References Inference genes 17564305 15829914 15756928 19417757 18628779 17394460 CAT CCL2 ICAM1 IL1A IL6 NFKB1 SELE TNF
Crohn's disease	18.92	References/Inference Genes References Inference genes 10700533 17914947 11339241 21829567 CCL2 CRP IFNG IL6 TLR4 TNF
Drug-induced liver injury	18.37	References/Inference Genes References Inference genes 24813929 22627062 17709330 8218930 21245496 25226513 7532385 26958860 22491424 12153990 15763341 21570397 19638433 20623750 21984482 19483685 14971821 21741958 17984051 22688006 9696492 18227147 ABCB1 CAT CCL2 CCR2 CYP2C9 DGAT2 HLA-A HLA-B HMOX1 IFNG IL1A IL6 LBP NFE2L2 TNF
Liver Cirrhosis, Experimental	18.25	References/Inference Genes References Inference genes 17072980 15996030 16085334 17347453 23341968 16610050 25380136 21163135 12389079 16953842 16025519 15492853 ABCB1 ASAH1 ASNS CCL2 CD36 GPAM HMOX1 IFNG INHBE LBP NFE2L2 SREBF1 TLR4 TNF
Breast carcinoma	17.3	References/Inference Genes References Inference genes 18511948 17516992 16298037 25322848 22311042 19435922 19446661 25151356 25753200 15496535 ABCB1 CAT CPT1A CXCL8 CXCR4 CYP3A4 HMOX1 IFNG IL6 NQO1 TNF
Rheumatoid arthritis	16.31	References/Inference Genes References Inference genes 2001072 19192274 20080907 22450443 12566094 8391952 1568518 17379860 22104130 ABCB1 CAT CRP CXCL8 CXCR4 IFNG IL6 TNF
PLASMODIUM FALCIPARUM BLOOD INFECTION LEVEL	15.41	References/Inference Genes References Inference genes CD36 ICAM1 TNF
Arthritis, Experimental	14.92	References/Inference Genes References Inference genes 19765281 7589090 20974942 21452922 22450443 17827786 9598899 20131233 19330884 19203382 ABCB1 CAT CRP IFNG IL6 TNF

Definition

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Mechanism of Action

Erythromycin Interacts with Diseases

Erythromycin Interacts with Genes

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Erythromycin

Definition

Description

Top Gene Interactions

Related Pathways

General Information

Mechanism of Action

Erythromycin Interacts with Diseases

Erythromycin Interacts with Genes

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

Interactions list

Contact

Navigation

Newsletter