Definition
A synthetic tetracycline derivative with similar antimicrobial activity.
Description
A synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (malaria, falciparum). [PubChem]
Top Gene Interactions
Related Pathways
General Information
- Metabolism: Hepatic Route of Elimination: They are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations in a biologically active form. Half Life: 18-22 hours
- Uses/Sources: Doxycycline is indicated for use in respiratory tract infections caused by Mycoplasma pneumoniae, Haemophilus influenzae, Streptococcus pneumoniae, Legionella spp., or Klebsiella spp. It is also used for prophylaxis of malaria. Doxycycline is indicated for a variety of bacterial infections, from Mycobacterium fortuitum and M. marinum, to susceptible E. coli and Brucella spp. It can be used as an alternative to treating plague, tetanus, Campylobacter fetus
- Health Effects: Side effects from normal doses of tetracyclines are relatively minimal, but of particular note is phototoxicity. Tetracylclines increase the risk of sunburn under exposure to light from the sun or other sources. Tetracyclines may also cause stomach or bowel upsets, and, on rare occasions, allergic reactions. Very rarely, severe headache and vision problems may be signs of dangerous secondary intracranial hypertension, also known as pseudotumor cerebri. Tetracyclines are teratogens and cause tooth discolouration and poor tooth mineralization in the fetus as they develop in infancy. Symptoms of tetracycline overdose include anorexia, nausea, diarrhea, glossitis, dysphagia, enterocolitis and inflammatory lesions, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia.
- Symptoms: Symptoms of overdose include anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia.
- Treatment: Drug therapy is discontinued immediately; exchange transfusion may be required to remove the drug. Sometimes, phenobarbital (UGT induction) is used.
- Route of Exposure: Completely absorbed following oral administration.
Toxicity
- Carcinogenicity: No indication of carcinogenicity to humans (not listed by IARC).
- Toxicity: LD50=262 mg/kg (I.P. in rat).
Mechanism of Action
Target Name | Mechanism of Action | References |
---|---|---|
12S RNA Protein-arginine deiminase type-4 Beta-2-microglobulin |
17964793 21068391 |
Doxycycline Interacts with Diseases
Disease | Inference Score | References/Inference Genes |
Liver Cirrhosis, Experimental | 30.55 | |
Lung Neoplasms | 26.47 | |
Reperfusion Injury | 25.17 | |
Myocardial infarction | 25.0 | |
Diabetes Mellitus, Experimental | 24.71 | |
Colonic neoplasm | 24.01 | |
Breast carcinoma | 23.17 |
References/Inference Genes
|
Marfan Syndrome | 22.95 |
References/Inference Genes
|
Prostatic Neoplasms | 21.18 |
References/Inference Genes
|
Amyotrophic lateral sclerosis 1 | 19.11 | |
Thoracic aortic aneurysm | 18.29 |
References/Inference Genes
|
Dermatitis, Contact | 18.28 |
References/Inference Genes
|
Calcinosis | 18.09 |
References/Inference Genes
|
Hepatocellular carcinoma | 17.16 | |
Intracerebral hemorrhage | 16.76 | |
Carcinoma | 16.62 | |
Disease Progression | 15.5 | |
Asthma | 15.0 | |
Rheumatoid arthritis | 14.77 | |
Neoplasm Metastasis | 14.62 |