Top Gene Interactions
- Metabolism: Probably hepatic. Although colchicine metabolites have not been identified in humans, metabolism by mammalian hepatic microsomes has been demonstrated in vitro. Route of Elimination: In healthy volunteers (n=12) 40 - 65% of 1 mg orally administered colchicine was recovered unchanged in urine. Enterohepatic recirculation and biliary excretion are also postulated to play a role in colchicine elimination. Half Life: Elimination half-life is approximately 1 hour in healthy subjects, although a study with an extended sampling time reported mean terminal elimination half-life values of approximately 9 to 10.5 hours. Other studies have reported half-life values of approximately 2 hours in patients with alcoholic cirrhosis and approximately 2.5 hours in patients with familial Mediterranean fever.
- Uses/Sources: For treatment and relief of pain in attacks of acute gouty arthritis.
- Route of Exposure: Colchicine is rapidly absorbed after oral administration, probably from the jejunum and ileum. However, the rate and extent of absorption are variable, depending on the tablet dissolution rate; variability in gastric emptying, intestinal motility, and pH at the absorption site; and the extent to which colchicine is bound to microtubules in gastrointestinal mucosal cells.
Mechanism of Action
|Target Name||Mechanism of Action||References|
Tubulin beta chain
Cellular tumor antigen p53
Tubulin beta-1 chain
Cytochrome P450 3A4
Multidrug resistance protein 1
Nuclear receptor subfamily 0 group B member 1
ATPase family AAA domain-containing protein 5
Solute carrier family 22 member 3
Steroidogenic factor 1